Resolving ATM Haplotypes in Whites

Recurrent ATM mutations in T-PLL on diverse haplotypes: no support for their germline origin.

ATM haplotypes and cellular response to DNA damage: association with breast cancer risk and clinical radiosensitivity.

The ATM gene, mutated in the cancer-prone and radiation-sensitive syndrome ataxia-telangiectasia (AT), could predispose to breast cancer (BC) development and adverse radiotherapy responses. Sixteen ATM variants were genotyped in 254 BC cases, 70 of whom were adverse radiotherapy responders (RS-BC), and 312 control subjects and the ATM haplotypes were constructed. Constitutive ATM protein, cell ...

Caught in the Middle: Defensive Responses to IAT Feedback Among Whites, Blacks, and Biracial Black/Whites

This study used archival data to examine how White, Black, and biracial Black/White people respond to implicit attitude feedback suggesting that they harbor racial bias that does not align with their self-reported attitudes. The results suggested that people are generally defensive in response to feedback indicating that their implicit attitudes differ from their explicit attitudes. Among monor...

Toll-Interacting Protein in Resolving and Non-Resolving Inflammation

Innate leukocytes manifest dynamic and distinct inflammatory responses upon challenges with rising dosages of pathogen-associated molecular pattern molecules such as lipopolysaccharide (LPS). To differentiate signal strengths, innate leukocytes may utilize distinct intracellular signaling circuitries modulated by adaptor molecules. Toll-interacting protein (Tollip) is one of the critical adapto...

Levels of mineralocorticoids in whites and blacks.

Blacks appear, on average, to retain more Na than whites. A higher production rate of mineralocorticoids could explain the greater Na retention in blacks. Although production of aldosterone has been shown to be lower in blacks, the level of another mineralocorticoid may be increased. Plasma levels of deoxycorticosterone and cortisol were measured in young whites (n=23; age=16.4+/-3.1[SD] years)...